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KMID : 0350519960490041253
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Journal of Catholic Medical College
1996 Volume.49 No. 4 p.1253 ~ p.1266
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The Effect of Corpus Callosotomy on the Generalization of Seizure in the Lithium-Pilocarpine
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Abstract
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Section of the corpus callosum (SCC) is a useful surgical therapy in selected types of epilepsy, i.e., tonic, atonic, and intractable generalized convulsive seizures. But the mechanism of therapeutic efficacy of SCC on epilepsy is still unknown.
Experimentally, the effects of SCC have been studied in animal models of focal seizures as well as generalized seizures. Recently, lithium-pilocarpine model of status epilepticus has been known as a animal model for the studing of the
epileptogenesis
and pathogenesis of generalized seizures, and the c-fos protein (Fos) immunohistochemistry has been used as a metabolic marker for tracing neuroanatomical connection, seizure pathways, and sites of action of neuroactive drugs. It has been
reported
that
Fos was expressed massively in cerebral cortex and limbic area at 4 hours after lithium-pilocarpine injection in rats.
@ES The results were as follows:
@EN 1. In the SCC group, four (40%) rats never developed status epilepticus, among them two (20%) never exhibited any seizure, while all of the control group developed seizure and status epilepticus. None of the SCC animals died after 24 hours
but
70%
of the control animals died within 24 hours of status epilepticus. This was significantly different (P<0.05).
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KEYWORD
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